National Institute for Health Research, Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address: p.n.newsome@bham.ac.uk. Shire Plc, a Takeda company, Lexington, MA, USA. Kansas City Research Institute, Kansas City, MO, USA. Fresno Clinical Research Center, Fresno, CA, USA. GI Specialists of Georgia, Marietta, GA, USA. DHAT Research Institute, Garland, TX, USA. Quality Medical Research, PLLC, Nashville, TN, USA. Methodist Health System Clinical Research Institute, Dallas, TX, USA. Inland Empire Liver Foundation, Rialto, CA, USA. Southern California Research Center, Coronado, CA, USA. National Institute for Health Research, Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.